ISBN: 9783527655779
Closing a gap in the scientifi c literature, this first comprehensive introduction to the topic is based on current best practice in one of the largest pharmaceutical companies worldwide.… More...
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2012, ISBN: 9783527655779
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2012, ISBN: 9783527655779
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2012, ISBN: 9783527655779
eBooks, eBook Download (PDF), 1. Auflage, [PU: Wiley-VCH], Wiley-VCH, 2012
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ISBN: 9783527655779
Closing a gap in the scientifi c literature, this first comprehensive introduction to the topic is based on current best practice in one of the largest pharmaceutical companies worldwide.… More...
Amit S. Kalgutkar; Deepak Dalvie; R. Scott Obach; Dennis A. Smith:
Reactive Drug Metabolites - First edition2012, ISBN: 9783527655779
eBooks, eBook Download (PDF), 1. Auflage, Closing a gap in the scientifi c literature, this first comprehensive introduction to the topic is based on current best practice in one of the l… More...
2012
ISBN: 9783527655779
eBooks, eBook Download (PDF), Auflage, [PU: Wiley-VCH], [ED: 1], Wiley-VCH, 2012
2012, ISBN: 9783527655779
[ED: 1], Auflage, eBook Download (PDF), eBooks, [PU: Wiley-VCH]
2012, ISBN: 9783527655779
eBooks, eBook Download (PDF), 1. Auflage, [PU: Wiley-VCH], Wiley-VCH, 2012
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Details of the book - Reactive Drug Metabolites
EAN (ISBN-13): 9783527655779
ISBN (ISBN-10): 3527655778
Publishing year: 2012
Publisher: Wiley-VCH
402 Pages
Language: eng/Englisch
Book in our database since 2012-04-10T19:25:07+01:00 (London)
Detail page last modified on 2023-06-19T18:03:57+01:00 (London)
ISBN/EAN: 9783527655779
ISBN - alternate spelling:
3-527-65577-8, 978-3-527-65577-9
Alternate spelling and related search-keywords:
Book author: kubin, douglas, kubinyi, mann, deepak, hugo, amit, raimund, doug scott, schwab, adolf, folkers, smith dennis
Information from Publisher
Author: Amit S. Kalgutkar; Deepak Dalvie; R. Scott Obach; Dennis A. Smith
Title: Methods and Principles in Medicinal Chemistry; Reactive Drug Metabolites
Publisher: Wiley-VCH; Wiley-VCH
386 Pages
Publishing year: 2012-09-04
Language: English
153,99 € (DE)
153,99 € (AT)
Available
EA; E107; E-Book; Nonbooks, PBS / Chemie; Medizinische Chemie, Pharmazeutische Chemie; Verstehen; Basic Pharmacology; Chemie; Chemistry; Drug Discovery & Development; Grundlagen der Pharmakologie; Medical Science; Medizin; Toxicology; Toxikologie; Wirkstoffforschung; Wirkstoffforschung u. -entwicklung; Wirkstoffforschung u. -entwicklung; Toxikologie; Grundlagen der Pharmakologie; BB
Closing a gap in the scientifi c literature, this first comprehensive introduction to the topic is based on current best practice in one of the largest pharmaceutical companies worldwide. The first chapters trace the development of our understanding of drug metabolite toxicity, covering basic concepts and techniques in the process, while the second part details chemical toxicophores that are prone to reactive metabolite formation. This section also reviews the various drug-metabolizing enzymes that can participate in catalyzing reactive metabolite formation, including a discussion of the structure-toxicity relationships for drugs. Two chapters are dedicated to the currently hot topics of herbal constituents and IADRs. The next part covers current strategies and approaches to evaluate the reactive metabolite potential of new drug candidates, both by predictive and by bioanalytical methods. There then follows an in-depth analysis of the toxicological potential of the top 200 prescription drugs, illustrating the power and the limits of the toxicophore concept, backed by numerous case studies. Finally, a risk-benefi t approach to managing the toxicity risk of reactive metabolite-prone drugs is presented. Since the authors carefully develop the knowledge needed, from fundamental considerations to current industry standards, no degree in pharmacology is required to read this book, making it perfect for medicinal chemists without in-depth pharmacology training.More/other books that might be very similar to this book
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