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Brodt, Pnina:

Liver Metastasis: Biology and Clinical Management / Pnina Brodt / Buch / Cancer Metastasis - Biology and Treatment / Book / Englisch / 2011 - hardcover

2011, ISBN: 9789400702912

[ED: Gebunden], [PU: Springer Netherland], Liver metastases are a frequent and often fatal occurrence in cancer patients, particularly those with malignancies of the gastrointestinal (GI)… More...

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Brodt, Pnina:

Liver Metastasis: Biology and Clinical Management Pnina Brodt Buch Cancer Metastasis - Biology and Treatment Book Englisch 2011 - hardcover

2011, ISBN: 9789400702912

[ED: Gebunden], [PU: Springer Netherland], Liver metastases are a frequent and often fatal occurrence in cancer patients, particularly those with malignancies of the gastrointestinal (GI)… More...

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Pnina Brodt:
Liver Metastasis: Biology and Clinical Management - new book

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ISBN: 9789400702912

[ED: Buch], [PU: Springer-Verlag GmbH], Neuware - Liver metastases are a frequent and often fatal occurrence in cancer patients, particularly those with malignancies of the gastrointestin… More...

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Springer Netherland:
Liver Metastasis: Biology and Clinical Management - hardcover

2011, ISBN: 9789400702912

Liver metastases are a frequent and often fatal occurrence in cancer patients, particularly those with malignancies of the gastrointestinal (GI) tract. While recent improvements in surgic… More...

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Pnina Brodt:
Liver Metastasis: Biology and Clinical Management - new book

2001, ISBN: 9789400702912

[ED: Buch], [PU: Springer-Verlag GmbH], Neuware - Liver metastases are a frequent and often fatal occurrence in cancer patients, particularly those with malignancies of the gastrointestin… More...

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Details of the book
Liver Metastasis: Biology and Clinical Management

Liver metastases are a frequent and often fatal occurrence in cancer patients, particularly those with malignancies of the gastrointestinal (GI) tract. While recent improvements in surgical techniques and a more aggressive approach to resection of liver metastases have improved long term survival for some patients, most patients with hepatic metastases still succumb to their disease. To improve these dismal statistics, a better understanding of the biology of liver metastasis, particularly the early stages that can be targeted for prevention, is essential.   Once cancer cells enter the liver, several different scenarios may occur. The cancer cells may be immediately destroyed by local defence mechanisms, they may enter a state of dormancy as solitary cells and never produce a metastasis, initiate a short-lived process of proliferation that is aborted before a metastasis is established or actively proliferate to form macrometastases. The chapters in Part I of this book provide insight into the cellular/molecular mechanisms that determine which of these scenarios prevails.   Written by experts researchers in the filed of metastasis, these chapters provide state-of-the art reviews on the cellular and molecular processes that impact the early stages of the metastatic process. The unique microenvironment of the liver, its various anatomical, cellular and molecular features and the impact they have on metastasis are highlighted. In addition, the role of inflammation (pre-existing and tumor-induced), host innate and adaptive immune responses, cytokines, chemokines, growth factors and the unique molecular signatures of metastatic tumor cells are reviewed with an underscoring of the translational implications of the current state of knowledge.   Against this background, the chapters in Part II of the book provide critical reviews on major aspects of the clinical management of hepatic metastases. These include imaging strategies, surgical and chemotherapeutic treatment approaches and the use of targeted biological therapeutics such as anti-angiogenic drugs as treatment modalities. By combining information on biological and clinical aspects of liver metastasis, this volume  will serve as an excellent resource for scientists, clinicians, clinician/ scientists and trainees in the domains of oncology, surgical oncology, hepatobiliary physiology and radiology.

Details of the book - Liver Metastasis: Biology and Clinical Management


EAN (ISBN-13): 9789400702912
ISBN (ISBN-10): 9400702914
Hardcover
Publishing year: 2011
Publisher: Springer
446 Pages
Weight: 0,804 kg
Language: eng/Englisch

Book in our database since 2007-05-27T03:49:01+01:00 (London)
Detail page last modified on 2022-04-11T08:30:12+01:00 (London)
ISBN/EAN: 9789400702912

ISBN - alternate spelling:
94-007-0291-4, 978-94-007-0291-2
Alternate spelling and related search-keywords:
Book author: brodt
Book title: liver metastases, metastasis, management clinical, metastasier


Information from Publisher

Author: Pnina Brodt
Title: Cancer Metastasis - Biology and Treatment; Liver Metastasis: Biology and Clinical Management
Publisher: Springer; Springer Netherland
446 Pages
Publishing year: 2011-03-04
Dordrecht; NL
Printed / Made in
Language: English
213,99 € (DE)
219,99 € (AT)
236,00 CHF (CH)
POD
XIV, 446 p.

BB; Hardcover, Softcover / Medizin/Nichtklinische Fächer; Onkologie; Verstehen; Breast cancer; Cancer and Inflammation; Colon cancer; Liver metastasis; Liver microenvironment; surgical oncology; Cancer Biology; Oncology; Cancer Therapy; Radiology; Immunology; Bildgebende Verfahren; Immunologie; BC

Liver metastases are a frequent and often fatal occurrence in cancer patients, particularly those with malignancies of the gastrointestinal (GI) tract. While recent improvements in surgical techniques and a more aggressive approach to resection of liver metastases have improved long term survival for some patients, most patients with hepatic metastases still succumb to their disease. To improve these dismal statistics, a better understanding of the biology of liver metastasis, particularly the early stages that can be targeted for prevention, is essential.   Once cancer cells enter the liver, several different scenarios may occur. The cancer cells may be immediately destroyed by local defence mechanisms, they may enter a state of dormancy as solitary cells and never produce a metastasis, initiate a short-lived process of proliferation that is aborted before a metastasis is established or actively proliferate to form macrometastases. The chapters in Part I of this book provide insight into the cellular/molecular mechanisms that determine which of these scenarios prevails.   Written by experts researchers in the filed of metastasis, these chapters provide state-of-the art reviews on the cellular and molecular processes that impact the early stages of the metastatic process. The unique microenvironment of the liver, its various anatomical, cellular and molecular features and the impact they have on metastasis are highlighted. In addition, the role of inflammation (pre-existing and tumor-induced), host innate and adaptive immune responses, cytokines, chemokines, growth factors and the unique molecular signatures of metastatic tumor cells are reviewed with anunderscoring of the translational implications of the current state of knowledge.   Against this background, the chapters in Part II of the book provide critical reviews on major aspects of the clinical management of hepatic metastases. These include imaging strategies, surgical and chemotherapeutic treatment approaches and the use of targeted biological therapeutics such as anti-angiogenic drugs as treatment modalities. By combining information on biological and clinical aspects of liver metastasis, this volume  will serve as an excellent resource for scientists, clinicians, clinician/ scientists and trainees in the domains of oncology, surgical oncology, hepatobiliary physiology and radiology.
Comprehensive and timely reviews on different aspects of the Biology of liver metastasis A unique combination of chapters on basic biological mechanisms and clinical aspects of liver metastasis written by experts in the respective fields Unlike other books now available on this subject, this book is not restricted to colon or GI cancers in its focus The Book will appeal to clinicians and laboratory scientists as well as trainees in both disciplines

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