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Molecular Analysis of B Lymphocyte Development and Activation (Current Topics in Microbiology and Immunology, Band 290)
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Molecular Analysis of B Lymphocyte Development and Activation (Current Topics in Microbiology and Immunology, Band 290) - Paperback

2014, ISBN: 9783642421884

Springer, Taschenbuch, Auflage: 2005, 272 Seiten, Publiziert: 2014-11-28T00:00:01Z, Produktgruppe: Book, Hersteller-Nr.: biography, 0.93 kg, Medizin, Kategorien, Bücher, Immunologie, Grun… More...

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Molecular Analysis of B Lymphocyte Development and Activation - Grosschedl, Rudolf (Herausgeber); Singh, Harinder (Herausgeber)
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Grosschedl, Rudolf (Herausgeber); Singh, Harinder (Herausgeber):

Molecular Analysis of B Lymphocyte Development and Activation - new book

2014, ISBN: 3642421881

2005 Kartoniert / Broschiert B cell receptor; DNA-binding proteins; biochemistry; cell; class switch recombination; cytokine; cytokine receptors; gene; genes; immunoglobulin; protein; p… More...

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Molecular Analysis of B Lymphocyte Development and Activation - Harinder Singh; Rudolf Grosschedl
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Harinder Singh; Rudolf Grosschedl:
Molecular Analysis of B Lymphocyte Development and Activation - Paperback

2014

ISBN: 9783642421884

Buch, Softcover, 2005, [PU: Springer Berlin], Springer Berlin, 2014

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Harinder Singh; Rudolf Grosschedl:
Molecular Analysis of B Lymphocyte Development and Activation - Paperback

2014, ISBN: 9783642421884

2005, Softcover, Buch, [PU: Springer Berlin]

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Rudolf Grosschedl:
Molecular Analysis of B Lymphocyte Development and Activation - new book

ISBN: 9783642421884

Livre, [PU: Springer, Berlin/Heidelberg/New York, NY]

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Bibliographic data of the best matching book

Details of the book
Molecular Analysis of B Lymphocyte Development and Activation
Author:
Title:
ISBN:

9783642421884


TheBlymphocytelineagerepresentsaleadingsystemforexploring- lecularmechanismsthatunderliecellfatespecification,differentiationand cellular activation. In the past five years major advances have been achievedintheanalysisofearlyBcelldevelopment,AIDdependentclass switchrecombinationaswellassomatichypermutationandBlimp-1re- latedplasmacelldifferentiation. Manyofthesefindingsandtheirimpli- tionsarecoveredinthisvolume. Twoemergentareasofresearchthatare includedinthecontributionsfocusonthepre-BCRandIkaros-familyp- teins. Thepre-BCRisanunusualmoleculardevicethatisusedtoexecute acriticaldevelopmentalcheckpointintheBlineage. Itsmechanismof- tion in relationto the pre-TCR and the mature antigen receptors (BCR, TCR)isofconsiderableinterest. Ikaros-familyproteinsappeartofunction viarecruitingtargetgenestodomainsofcentromericheterochromatinin the nucleus. Initially discovered in lymphocytes, they represent a novel system of gene regulationvia nuclearcompartmentalization. Finally, the volumeincludesachapteronWntsignalinginlymphopoiesis. Analysisof thisevolutionallyconservedpathwaywhichregulatescellularproliferation anddifferentiationindiversedevelopmentalcontextsbenefitedenormo- lyfromthediscoveryoftheLEF/TCFfamilyoffactorsinlymphocyticl- eages. ThisvolumeisdedicatedtothememoryofEugeniaSpanopoulou,ac- leagueandahighlyvaluedmemberofourscientificcommunity. Itc- tainsachapteronthebiochemistryofV(D)JrecombinationthatEugenia co-authoredwithDavidSchatz. Obituary Eugenia Spanopoulou was an extraordinary person and scientist. Her enormousintelligenceandenergysparkedimportantscientificdiscoveries, andvaultedhertoapointofbreathtakingpotential-apotentialabruptly erasedattheageof37withthecrashofSwissairflight111onSeptember 3,1998. Lostwithherwereherhusband,AndrewHodtsev,andyoungson, Platon. Eugeniawaspassionatelyinterestedinunderstandingthemolecular- sisofdevelopmentandchoseashermodelsystemthedevelopmentofB andTlymphocytes. Shebeganbystudyingthetranscriptionalregulation oftheTcell-specificge

Details of the book - Molecular Analysis of B Lymphocyte Development and Activation


EAN (ISBN-13): 9783642421884
ISBN (ISBN-10): 3642421881
Paperback
Publishing year: 2014
Publisher: Springer Berlin

Book in our database since 2015-02-06T15:15:10+00:00 (London)
Detail page last modified on 2022-02-24T11:50:12+00:00 (London)
ISBN/EAN: 9783642421884

ISBN - alternate spelling:
3-642-42188-1, 978-3-642-42188-4
Alternate spelling and related search-keywords:
Book author: singh, häri, rudolf gross, harin
Book title: analysis, molecular, lymphocytes, 290

Information from Publisher

Author: Harinder Singh; Rudolf Grosschedl
Title: Current Topics in Microbiology and Immunology; Molecular Analysis of B Lymphocyte Development and Activation
Publisher: Springer; Springer Berlin
260 Pages
Publishing year: 2014-11-28
Berlin; Heidelberg; DE
Printed / Made in
Language: English
160,49 € (DE)
164,99 € (AT)
177,00 CHF (CH)
POD
XI, 260 p.

BC; Hardcover, Softcover / Medizin/Nichtklinische Fächer; Immunologie; Verstehen; B cell receptor; DNA-binding proteins; biochemistry; cell; class switch recombination; cytokine; cytokine receptors; gene; genes; immunoglobulin; protein; proteins; transcriptional regulators; Immunology; BB; EA

Gene Regulatory Networks Orchestrating B Cell Fate Specification, Commitment, and Differentiation.- Helix-Loop-Helix Proteins in Lymphocyte Lineage Determination.- Ikaros-Family Proteins: In Search of Molecular Functions During Lymphocyte Development.- Biochemistry of V(D)J Recombination.- The pre-B cell Receptor in B Cell Development: Recent Advances, Persistent Questions and Conserved Mechanisms.- Transcriptional Control of B Cell Activation.- Expression of MHC II Genes.- Class Switch Recombination: An Emerging Mechanism.- Blimp-1; Immunoglobulin Secretion and the Switch to Plasma Cells.- Wnt Signaling in Lymphopoiesis.
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