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Protein-Protein Interactions as New Drug Targets - John Scott
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Protein-Protein Interactions as New Drug Targets - Paperback

2010, ISBN: 3642091946

[EAN: 9783642091940], New book, [SC: 9.42], [PU: Springer Berlin Heidelberg Okt 2010], COMPARTIMENTALISATION; PEPTIDEDISRUPTORS; PROTEIN-PROTEININTERACTIONS; SCAFFOLDINGPROTEINS; SMALLMOL… More...

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Protein-Protein Interactions as New Drug Targets (Handbook of Experimental Pharmacology, 186, Band 186)
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Protein-Protein Interactions as New Drug Targets (Handbook of Experimental Pharmacology, 186, Band 186) - Paperback

2010, ISBN: 9783642091940

Springer, Taschenbuch, Auflage: Softcover reprint of hardcover 1st ed. 2008, 527 Seiten, Publiziert: 2010-10-19T00:00:01Z, Produktgruppe: Buch, Hersteller-Nr.: 53 black & white illustrati… More...

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Protein-Protein Interactions as New Drug Targets: 186 (Handbook of Experimental Pharmacology, 186)
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Protein-Protein Interactions as New Drug Targets: 186 (Handbook of Experimental Pharmacology, 186) - Paperback

2010

ISBN: 9783642091940

Editor: Klussmann, Enno, Editor: Scott, John, Springer, Paperback, Auflage: Softcover reprint of hardcover 1st ed. 2008, 527 Seiten, Publiziert: 2010-10-19T00:00:01Z, Produktgruppe: Book,… More...

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Protein-Protein Interactions as New Drug Targets - Scott, John (Herausgeber); Klussmann, Enno (Herausgeber)
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Scott, John (Herausgeber); Klussmann, Enno (Herausgeber):
Protein-Protein Interactions as New Drug Targets - Paperback

2010, ISBN: 3642091946

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Softcover reprint of hardcover 1st ed. 2008 Kartoniert / Broschiert Pharmakologie, Medizinische Chemie, Pharmazeutische Chemie, Zellbiologie (Zytologie), Compartimentalisation; PeptideD… More...

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Protein-Protein Interactions as New Drug Targets - Scott John
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Protein-Protein Interactions as New Drug Targets - used book

ISBN: 9783642091940

Livre, [PU: Springer, Berlin/Heidelberg/New York, NY]

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Details of the book
Protein-Protein Interactions as New Drug Targets (Handbook of Experimental Pharmacology, 186, Band 186)
Author:
Title:
ISBN:

9783642091940


Disease-relevant intracellular protein-protein interactions occurring at defined cellular sites possess great potential as drug targets. They permit highly specific pharmacological interference with defined cellular functions. Drugs targeting such interactions are likely to act with fewer side effects than conventional medication influencing whole cell functions. This book discusses therapeutically relevant protein-protein interactions with a major focus on scaffolding proteins tethering signal transduction processes to defined cellular compartments by direct protein-protein interactions. Recent advances in the development of pharmacological agents interfering with protein-protein interactions are highlighted.

Details of the book - Protein-Protein Interactions as New Drug Targets (Handbook of Experimental Pharmacology, 186, Band 186)


EAN (ISBN-13): 9783642091940
ISBN (ISBN-10): 3642091946
Hardcover
Paperback
Publishing year: 2010
Publisher: Klussmann, Enno, Scott, John, Springer
528 Pages
Weight: 0,789 kg
Language: eng/Englisch

Book in our database since 2011-02-18T13:56:54+00:00 (London)
Detail page last modified on 2023-06-17T15:09:52+01:00 (London)
ISBN/EAN: 9783642091940

ISBN - alternate spelling:
3-642-09194-6, 978-3-642-09194-0
Alternate spelling and related search-keywords:
Book author: klußmann, enno von, klussmann, john scott, klüssmann
Book title: protein protein interactions, protein protein interaction

Information from Publisher

Author: Enno Klussmann; John Scott
Title: Handbook of Experimental Pharmacology; Protein-Protein Interactions as New Drug Targets
Publisher: Springer; Springer Berlin
512 Pages
Publishing year: 2010-10-19
Berlin; Heidelberg; DE
Printed / Made in
Language: English
320,99 € (DE)
329,99 € (AT)
354,00 CHF (CH)
POD
XV, 512 p.

BC; Hardcover, Softcover / Medizin/Pharmazie; Pharmakologie; Verstehen; Compartimentalisation; Peptide Disruptors; Protein-Protein Interactions; Scaffolding Proteins; Small Molecules; proteins; Pharmacology; Cell Biology; Medical Biochemistry; Biomedical Research; Zellbiologie (Zytologie); Medizinische Chemie, Pharmazeutische Chemie; Medizinische Forschung; BB

Organization of Scaffolds.- A-Kinase Anchoring Proteins as the Basis for cAMP Signaling.- Arrestins as Multi-Functional Signaling Adaptors.- Role of Ena/VASP Proteins in Homeostasis and Disease.- Scaffold/Matrix Attachment Regions (S/MARs): Relevance for Disease and Therapy.- Clathrin/AP-2-Dependent Endocytosis: A Novel Playground for the Pharmacological Toolbox?.- Scaffolding Proteins and Cellular Signalling.- PDE4 Associates with Different Scaffolding Proteins: Modulating Interactions as Treatment for Certain Diseases.- G-Protein-Coupled Receptor-Signaling Components in Membrane Raft and Caveolae Microdomains.- Protein Scaffolds, Lipid Domains and Substrate Recognition in Protein Kinase C Function: Implications for Rational Drug Design.- Compartmentalised MAPK Pathways.- Dynamic Protein Complexes Regulate NF-?B Signaling.- An Oncogenic Hub: ?-Catenin as a Molecular Target for Cancer Therapeutics.- A Toolkit for Real-Time Detection of cAMP: Insights into Compartmentalized Signaling.- Cell Type-Specific Anchoring.- Scaffolding Proteins in Cardiac Myocytes.- Molecular Architecture of Signal Complexes Regulating Immune Cell Function.- Scaffolding Proteins at the Postsynaptic Density: Shank as the Architectural Framework.- Interference with Protein-Protein Interaction Sites as a New Pharmacological Concept.- Domains Mediate Protein-Protein Interactions and Nucleate Protein Assemblies.- Proline-Rich Sequence Recognition Domains (PRD): Ligands, Function and Inhibition.- Chemical Inhibition Through Conformational Stabilization of Rho GTPase Effectors.- Pharmacological Interference with Protein-Protein Interactions Mediated by Coiled-Coil Motifs.- Direct AKAP-Mediated Protein-Protein Interactions as Potential Drug Targets.

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