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Bioisosteres in Medicinal Chem - Brown
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Bioisosteres in Medicinal Chem - hardcover

2012, ISBN: 9783527330157

Gebunden, 256 Seiten, 250mm x 175mm x 18mm, Sprache(n): eng Written with the practicing medicinal chemist in mind, this is the first modern handbook to systematically address the topic of… More...

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Bioisosteres in Medicinal Chemistry (Methods and Principles in Medicinal Chemistry, 54, Band 54)
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Bioisosteres in Medicinal Chemistry (Methods and Principles in Medicinal Chemistry, 54, Band 54) - First edition

2012, ISBN: 9783527330157

Hardcover

Series Editor: Mannhold, Raimund, Series Editor: Kubinyi, Hugo, Series Editor: Folkers, Gerd, Wiley-VCH, Gebundene Ausgabe, Auflage: 1. 256 Seiten, Publiziert: 2012-08-22T00:00:01Z, Produ… More...

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Bioisosteres in Medicinal Chem - Brown
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Brown:
Bioisosteres in Medicinal Chem - Paperback

ISBN: 9783527330157

*Bioisosteres in Medicinal Chem* - 1. Auflage / gebundene Ausgabe für 211.49 € / Aus dem Bereich: Bücher, Wissenschaft, Chemie Medien > Bücher nein Buch (gebunden) Hardcover;Naturwissensc… More...

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Bioisosteres in Medicinal Chemistry - Brown, Nathan (EDT)
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Brown, Nathan (EDT):
Bioisosteres in Medicinal Chemistry - hardcover

2012, ISBN: 3527330151

[EAN: 9783527330157], Neubuch, [PU: Wiley-VCH], Books

NEW BOOK. Shipping costs: EUR 29.09 GreatBookPricesUK, Castle Donington, DERBY, United Kingdom [72536976] [Rating: 5 (von 5)]
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Bioisosteres in Medicinal Chemistry - Nathan Brown
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Nathan Brown:
Bioisosteres in Medicinal Chemistry - hardcover

ISBN: 9783527330157

hardback, [PU: Wiley-VCH, Weinheim]

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Details of the book
Bioisosteres in Medicinal Chemistry (Methods and Principles in Medicinal Chemistry, 54, Band 54)
Author:
Title:
ISBN:

9783527330157


Written with the practicing medicinal chemist in mind, this is the first modern handbook to systematically address the topic of bioisosterism.
As such, it provides a ready reference on the principles and methods of bioisosteric replacement as a key tool in preclinical drug development.

The first part provides an overview of bioisosterism, classical bioisosteres and typical molecular interactions that need to be considered,
while the second part describes a number of molecular databases as sources of bioisosteric identification and rationalization. The third part
covers the four key methodologies for bioisostere identification and replacement: physicochemical properties, topology, shape, and overlays of
protein-ligand crystal structures. In the final part, several real-world examples of bioisosterism in drug discovery projects are discussed.

With its detailed descriptions of databases, methods and real-life case studies, this is tailor-made for busy industrial researchers with little time for reading, while remaining easily accessible to novice drug developers due to its systematic structure and introductory section.

Details of the book - Bioisosteres in Medicinal Chemistry (Methods and Principles in Medicinal Chemistry, 54, Band 54)


EAN (ISBN-13): 9783527330157
ISBN (ISBN-10): 3527330151
Hardcover
Paperback
Publishing year: 2012
Publisher: Brown, Nathan, Wiley-VCH
237 Pages
Weight: 0,638 kg
Language: Englisch

Book in our database since 2008-03-08T06:09:28+00:00 (London)
Detail page last modified on 2023-12-19T22:57:51+00:00 (London)
ISBN/EAN: 9783527330157

ISBN - alternate spelling:
3-527-33015-1, 978-3-527-33015-7
Alternate spelling and related search-keywords:
Book author: nath, nathan brown, wiley vch verlag gmbh, hugo kubinyi, gerd folkers
Book title: hugo, brown, principles chemistry, chem

Information from Publisher

Author: Nathan Brown
Title: Methods and Principles in Medicinal Chemistry; Bioisosteres in Medicinal Chemistry
Publisher: Wiley-VCH; Wiley-VCH
238 Pages
Publishing year: 2012-08-22
Printed / Made in
Weight: 0,624 kg
Language: English
162,00 € (DE)
166,60 € (AT)
Available
170mm x 240mm x 16mm

BB; Hardcover, Softcover / Chemie; Medizinische Chemie, Pharmazeutische Chemie; Verstehen; Biochemie u. Chemische Biologie; Biochemistry (Chemical Biology); Chemie; Chemistry; Computational Chemistry & Molecular Modeling; Computational Chemistry u. Molecular Modeling; Drug Discovery & Development; Medizinische Chemie; Wirkstoffforschung; Wirkstoffforschung u. -entwicklung; Wirkstoffforschung u. -entwicklung; Biochemie u. Chemische Biologie; Computational Chemistry u. Molecular Modeling

Written with the practicing medicinal chemist in mind, this is the first modern handbook to systematically address the topic of bioisosterism. As such, it provides a ready reference on the principles and methods of bioisosteric replacement as a key tool in preclinical drug development. The first part provides an overview of bioisosterism, classical bioisosteres and typical molecular interactions that need to be considered, while the second part describes a number of molecular databases as sources of bioisosteric identification and rationalization. The third part covers the four key methodologies for bioisostere identification and replacement: physicochemical properties, topology, shape, and overlays of protein-ligand crystal structures. In the final part, several real-world examples of bioisosterism in drug discovery projects are discussed. With its detailed descriptions of databases, methods and real-life case studies, this is tailor-made for busy industrial researchers with little time for reading, while remaining easily accessible to novice drug developers due to its systematic structure and introductory section.

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