Pharmacokinetics and Metabolism in Drug Design (Methods and Principles in Medicinal Chemistry, Band 31) - hardcover

EAN (ISBN-13): 9783527313686
ISBN (ISBN-10): 3527313680
Hardcover
Publishing year: 2006
Publisher: Wiley-VCH Verlag GmbH & Co. KGaA
187 Pages
Weight: 0,609 kg
Language: eng/Englisch

Book in our database since 2007-05-30T14:46:56+01:00 (London)
Detail page last modified on 2022-05-21T00:33:30+01:00 (London)
ISBN/EAN: 9783527313686

ISBN - alternate spelling:
3-527-31368-0, 978-3-527-31368-6
Alternate spelling and related search-keywords:
Book author: gerd folkers, raimund, hugo kubinyi, dennis smith, walker, han, van waterbeemd, don smith
Book title: drug metabolism, design methods, methods and principles medicinal chemistry, metabol, meta design, pharmacokinetics drugs

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Information from Publisher

Author: Dennis A. Smith; Han van de Waterbeemd; Don K. Walker
Title: Methods and Principles in Medicinal Chemistry; Pharmacokinetics and Metabolism in Drug Design
Publisher: Wiley-VCH
187 Pages
Publishing year: 2006-02-20
Weight: 0,520 kg
Language: English
125,00 € (DE)
Not available (reason unspecified)

BB; GB; Hardcover, Softcover / Chemie; Verstehen; Pharmakokinetik; Arzneimitteldesign

PHYSICOCHEMISTRY Partition and Distribution Coefficient as Measures of Lipophilicity Limitations on the Use of Octanol Further Understanding of log P Alternative Lipophilicity Scales Computational Approaches to Lipophilicity Membrane Systems to Study Drug Behaviour NEW: Dissolution and Solubility NEW: Ionisation (pKa) PHARMACOKINETICS Intravenous Administration: Volume of Distribution Intravenous Administration: Clearance Clearance and Half-Life Intravenous administration: Infusion Oral Administration Repeated Doses Development of the Unbound (Free) Drug Model Unbound Drug and Drug Action Unbound Drug Model and Barriers to Equilibrium Slow Offset Compounds Factors Governing Unbound Drug Concentration ABSORPTION The Absorption Process Dissolution Membrane Transfer Barriers to Membrane Transfer Models for Absorption Estimation Estimation of Absorption Potential Computational Approaches DISTRIBUTION Membrane Transfer Access to the Target Brain penetration Volume of Distribution and Duration Distribution and Tmax CLEARANCE The Clearance Processes Role of Transport Proteins in Drug Clearance Interplay Between Metabolic and Renal Clearance Role of Lipophilicity in Drug Clearance RENAL CLEARANCE Kidney Anatomy and Function Lipophilicity and Reabsorption by the Kidney Effect of Charge on Renal Clearance Plasma Protein Binding and Renal Clearance Balancing Renal Clearance and Absorption Renal Clearance and Drug Design METABOLIC (HEPATIC) CLEARANCE Function of Metabolism (Biotransformation) Cytochrome P450 Other oxidative processes Oxidative Metablism and Drug Design Non-Specific Esterases Prodrugs to Aid Membrane Transfer Enzymes Catalysing Drug Conjugation Stability to Conjugation Processes Pharmacodynamics and Conjugation TOXICITY Toxicity Findings Importance of dose size Toxicity of selected compound classes Stratification of Toxicity Toxicity Prediction - Computational Toxicology Toxicogenomics Enzyme Induction (CYP3A4) and Drug Design Enzyme Inhibition and Drug Design INTERSPECIES SCALING Objectives of Allometric Scaling Allometric Scaling Species Scaling: Adjusting for Maximum Life-Span Potential Species Scaling: Incorporating Differences in Metabolic Clearance Inter-Species Scaling for Clearance by Hepatic Uptake Elimination Half-Life NEW: Scaling to pharmacological effect NEW: Single animal scaling HIGH(ER) THROUGHPUT ADME STUDIES The HTS Trend Drug Metabolism and Discovery Screening Sequences Physicochemistry Absorption / Permeability Pharmacokinetics NEW: Metabolism and Inhibition NEW: The concept of ADME space Computational Approaches in PK and Metabolism Prediction Outlook