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Chemical Carcinogenesis
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Chemical Carcinogenesis - new book

ISBN: 9781617379949

This volume will provide a contemporary account of advances in chemical carcinogenesis. It will promote the view that it is chemical alteration of the DNA that is a route cause of many ca… More...

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Chemical Carcinogenesis (Current Cancer Research) - Penning
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Chemical Carcinogenesis (Current Cancer Research) - hardcover

2011, ISBN: 9781617379949

[ED: Gebundene Ausgabe], [PU: Springer], EAN: 9781617379949 Das Titelbild der Auflage kann abweichen. Buch mit Gebrauchsspuren und vereinzelten Knicken, Flecken oder mit Gebrauchsspuren a… More...

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Chemical Carcinogenesis - Penning, Trevor M.
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Penning, Trevor M.:
Chemical Carcinogenesis - hardcover

2011

ISBN: 9781617379949

[ED: Gebunden], [PU: Humana Press], Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Focuses of this volume: chemical carcinogenesis, expos… More...

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Chemical Carcinogenesis (Current Cancer Research) - Penning
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Penning:
Chemical Carcinogenesis (Current Cancer Research) - hardcover

2011, ISBN: 9781617379949

Springer, Hardcover, Auflage: 2011, 456 Seiten, Publiziert: 2011-03-03T00:00:01Z, Produktgruppe: Book, 0.85 kg, Verkaufsrang: 10885413, Oncology, Internal Medicine, Medicine, Medical Book… More...

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Chemical Carcinogenesis - Penning, Trevor M. (Herausgeber)
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Penning, Trevor M. (Herausgeber):
Chemical Carcinogenesis - hardcover

2011, ISBN: 1617379948

2011 Gebundene Ausgabe Krebs (Krankheit), Tumor / Krebs, Arznei / Arzneimittellehre, Pharmakologie, Toxikologie, Pharmacology, Cancer; cancerresearch, mit Schutzumschlag 11, [PU:Humana … More...

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Bibliographic data of the best matching book

Details of the book
Chemical Carcinogenesis (Current Cancer Research)

This volume will provide a contemporary account of advances in chemical carcinogenesis. It will promote the view that it is chemical alteration of the DNA that is a route cause of many cancers. The multi-stage model of chemical carcinogenesis, exposure to major classes of human carcinogens and their mode-of-action will be a focal point. The balance between metabolic activation to form biological reactive intermediates and their detoxification, ensuing DNA-lesions and their repair will be profiled. It will describe the chemical changes that occur in DNA that result from endogenous insults including epigenetic changes that lead to gene silencing. It will describe major mechanisms of mutagenesis, affects on tumor suppressor genes and proto-oncogenes, and how cell-cycle check points can be by-passed by the "stealth-like" properties of chemical carcinogens. Environmental agents that can promote tumor formation will be discussed. The monograph will have wide appeal as a knowledge base for graduate students, post-doctoral fellows and faculty interested in this aspect of cancer causation and research.

Details of the book - Chemical Carcinogenesis (Current Cancer Research)


EAN (ISBN-13): 9781617379949
ISBN (ISBN-10): 1617379948
Hardcover
Publishing year: 2011
Publisher: Springer
440 Pages
Weight: 0,809 kg
Language: eng/Englisch

Book in our database since 2007-05-03T03:55:00+01:00 (London)
Detail page last modified on 2024-03-07T10:47:00+00:00 (London)
ISBN/EAN: 9781617379949

ISBN - alternate spelling:
1-61737-994-8, 978-1-61737-994-9
Alternate spelling and related search-keywords:
Book author: penning, trevor


Information from Publisher

Author: Trevor M. Penning
Title: Current Cancer Research; Chemical Carcinogenesis
Publisher: Humana; Humana Press
440 Pages
Publishing year: 2011-03-03
Totowa; NJ; US
Printed / Made in
Weight: 0,846 kg
Language: English
235,39 € (DE)
241,99 € (AT)
260,00 CHF (CH)
POD
XVI, 440 p. With 2 16 page color inserts.

BB; Cancer Research; Hardcover, Softcover / Medizin/Nichtklinische Fächer; Onkologie; Verstehen; Cancer; Cancer Research; Carcinogenesis; Chemical; Pharmacology/Toxicology; Cancer Biology; Pharmacology; Pharmakologie; BC; EA

This volume will provide a contemporary account of advances in chemical carcinogenesis. It will promote the view that it is chemical alteration of the DNA that is a route cause of many cancers. The multi-stage model of chemical carcinogenesis, exposure to major classes of human carcinogens and their mode-of-action will be a focal point. The balance between metabolic activation to form biological reactive intermediates and their detoxification, ensuing DNA-lesions and their repair will be profiled. It will describe the chemical changes that occur in DNA that result from endogenous insults including epigenetic changes that lead to gene silencing. It will describe major mechanisms of mutagenesis, affects on tumor suppressor genes and proto-oncogenes, and how cell-cycle check points can be by-passed by the "stealth-like" properties of chemical carcinogens. Environmental agents that can promote tumor formation will be discussed. The monograph will have wide appeal as a knowledge base for graduate students, post-doctoral fellows and faculty interested in this aspect of cancer causation and research.

1.      Historical Overview of Chemical Carcinogenesis

2.      Multistage Carcinogenesis

3.      Tobacco Smoke Carcinogens and Lung Cancer

4.      Mechanisms of Estrogen Carcinogenesis: Modulation by Botanical Natural Products

5.      Heterocyclic Amines: Potential Human Carcinogens

6.      Aflatoxins and Hepatocellular Carcinoma

7.      Metabolic Activation of Chemical Carcinogens

8.      Detoxication of  Chemical Carcinogens and Chemoprevention

9.      Covalent Polycyclic Aromatic Hydrocarbon-DNA Adducts, Carcinogenicity, Structure and Function

10.  Oxidation and Deamination of DNA by Endogenous Sources

11.  Lipid Peroxide-DNA Adducts

12.  Chemical Carcinogenesis and  Epigenetics

13.  Nucletoide Excision Repair From Bacteria to Humans: Structure-Function Studies

14.  Base Excision Repair: Role of DNA Polymerase b in Late Stage Base Excision Repair

-Alkylguanine-DNA alkyltransferase

16.  By-Pass DNA Polymerases

17.  Mutagenesis: The Outcome of Faulty Replication of DNA

18.  p53 and Ras-Mutation

Focuses of this volume: chemical carcinogenesis, exposure to major classes of human carcinogens and their mode-of-action, the balance between metabolic activation to form biological reactive intermediates and their detoxification, and environmental agents that can promote tumor formation

appeals to graduate students, post-doctoral fellows and faculty interested in this aspect of cancer causation and research



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