ISBN: 0521887216

EAN: 9780521887212. Further scientific dissection of the underlying pathways is required to pave the way for new therapeutic targets. Section 1. Bone complications of myeloma and lymphoma… More...

EAN: 9780521887212. Further scientific dissection of the underlying pathways is required to pave the way for new therapeutic targets. Section 1. Bone complications of myeloma and lymphoma. Cambridge University Press. img{max-width:100%}Cancer Metastasis: Biologic Basis and TherapeuticsCambridge University PressHardcoverUnused and unread, minor cosmetic imperfections such as scuffing or minor creasing. Stamped 'damaged' by publisher to a non-text page.EAN: 9780521887212Published 25/04/2011Language: EnglishMetastasis is responsible for a large burden of morbidity and mortality among cancer patients, and currently few therapies specifically target metastatic disease. Further scientific dissection of the underlying pathways is required to pave the way for new therapeutic targets. This groundbreaking new text comprehensively covers the processes underlying cancer metastasis and the clinical treatment of metastatic disease. Whereas previous volumes have been compendia of laboratory research articles, the internationally renowned authors of this volume have summarized the state-of-the-art research in the metastasis field. A major section covers the cellular and molecular pathways of metastasis and experimental techniques and the systems and models applied in this field. Subsequently, the clinical aspects of the major cancer types are considered, focusing on disease-specific research and therapeutic approaches to metastatic disease. The focus is on novel pathophysiological insights and emerging therapies; future directions for research and unmet clinical needs are also discussed.Overviewbiology is the foundation of therapyPart I.Ã? Basic ResearchIntroduction to basic researchSection 1. Models and Tools for Metastasis Studies1. Animal models of cancer metastasis2. Drosophila and zebrafishgenetic models for cancer metastasis3.Ã? Computational models4.Ã? Intravital microscopy to visualize invasion and metastasisSection 2. Genes5.Ã? Metastasis-promoting genes6.Ã? The role of metastasis suppressor genes in metastasis7. Stromal-derived factors that dictate organ-specific metastasis8. Metastasis genesepigenetics9. Germline variation and other host determinants of metastatic potential10.Ã? The influence of aging and cellular senescence on metastasisSection 3. Various Properties of Cancer Cells11.Ã? The continuum of epithelial mesenchymal transition - implication of hybrid states for migration and survival in development and cancer12. Apoptosis, anoikis, and senescence13.Ã? Metastatic inefficiency and tumor dormancySection 4. Stromal Cells/Extracellular Matrix14. Role of inflammation in metastatic progression15.Ã? Proteolytic cascades in invasion and metastasis16.Ã? Role of matrix metalloproteinases in tumor invasion and metastasis17. Cell-derived microvesicles and metastasisSection 5. Systemic Factors18. Exploring the earliest steps in metastasisthe pre-metastatic niche19. Growth regulatory pathways contributing to organ selectivity of metastasis20. Determinants of organ-specific metastasis21. Function and expression of the uPA/uPAR system in cancer metastasis22. The lymphaticson the route to cancer metastasisPart II.Ã? Clinical Research23. Introduction to clinical research24. Sarcoma25. Neuroblastoma26. Retinoblastoma27. Primary brain tumors and cerebral metastases28. Head and neck cancer metastasis29. Cutaneous melanomatherapeutic approaches for metastatic disease30. Gastric cancer metastasis31. Metastatic pancreatic cancer32. Metastasis of primary liver cancer33. Advances in management of metastatic colorectal cancer34. Lung cancer metastasis35. Metastatic thyroid cancerevaluation and treatment36. Metastatic renal cell carcinoma37. Bladder cancer38. Bone complications of myeloma and lymphoma39. Breast metastasis40. Gynecologic malignancies41. Prostate cancer metastasisthoughts on biology and therapeutics42. The biology and treatment of metastatic testicular cancer43. Applications of proteomics to metastasis diagnosis and individualized therapy44. Critical issues of research on circulating and disseminated tumor cells in cancer patients45. Ã? Lymphatic mapping and sentinel lymph node biopsy46. Molecular imaging and metastasis47. Preserving bone health in malignancy and complications of bone metastases48. Role of platelets and thrombin in metastasisSection 6. Therapies49. Cancer nanotechnology offers great promise for cancer research and therapy50. Metronomic chemotherapy for treatment of metastatic diseasefrom preclinical research to clinical trials51. Immunotherapy52. Discovery and development of drugs targeting tumor invasion and metastasis53. The role of radiotherapy in the treatment of metastatic disease54. Prospects for clinical trials of metastasis inhibitors. DispatchIn stock here - same-day dispatch from England. My SKU: 3252945RefundsNo-hassle refunds are always available if your book is not as expected.Terms and Conditions of SaleSorry - no collections. All sales are subject to extended Terms and Conditions of Sale as well as the Return Policy and Payment Instructions. Visit my eBay Store for details andmany more books. Template layout and design, "JNC Academic Books", "needbooks", Copyright © JNC INC. Designated trademarks, layouts and brands are the property of their respective owners. All Rights Reserved., Neuwertig, Festpreisangebot, [LT: FixedPrice], Title: Cancer Metastasis: Biologic Basis and Therapeutics, Pages: 660, Publication Year: 2011, Type: Textbook, Format: Hardcover, Publication Name: Cancer Metastasis: Biologic Basis and Therapeutics, Item Height: 287mm, Item Width: 223mm, Subject: Medicine, Item Weight: 2050g, Number of Pages: 660 Pages, Cambridge University Press<