2009, ISBN: 9783838302775

Kartoniert, 188 Seiten, 220mm x 150mm x 12mm, Sprache(n): eng Cell cycle checkpoints are the means by which cells maintain their genomic integrity and resist factors that are potentially … More...

Kartoniert, 188 Seiten, 220mm x 150mm x 12mm, Sprache(n): eng Cell cycle checkpoints are the means by which cells maintain their genomic integrity and resist factors that are potentially mutagenic. It is well known that there are different checkpoints for different stresses a cell could face, one of them being the DNA damage checkpoint. For long the activity of this checkpoint was thought to be limited to the nucleus. In this and other emerging studies it has now been established that the DNA damage checkpoint can regulate cell cycle arrest, nuclear positioning and movement by controlling cytoplasmic factors and events. This study establishes a novel regulatory mechanism of the DNA damage checkpoint involving vesicular transport system and cytoplasmic, non-proteosomal protein degradation. The study also focuses on the connection between the spindle assembly checkpoint (SAC) and the DNA damage checkpoint. To study this we generate an acentric chromosome with a single DNA double strand break on it. We find that budding yeast cells that have one chromosome with conditional GAL1-Cen centromere turned off cannot activate the SAC and both the sister chromatids of this chromosome get preferentially segregated to the mother cell.I left a career in medicine to follow my dream of bettering ourunderstanding of diseases like cancer. My research as a Ph.D. student was in thefield of DNA damage under the guidance of Prof. James Haber. We studied the cellularmechanisms involved in sensing and repairing the DNA damage, which if unchecked couldlead to cell death or cancer. Versandkostenfreie Lieferung<

ISBN: 9783838302775

Paperback, [PU: LAP LAMBERT Academic Publishing], Cell cycle checkpoints are the means by which cells maintain their genomic integrity and resist factors that are potentially mutagenic. I… More...

Paperback, [PU: LAP LAMBERT Academic Publishing], Cell cycle checkpoints are the means by which cells maintain their genomic integrity and resist factors that are potentially mutagenic. It is well known that there are different checkpoints for different stresses a cell could face, one of them being the DNA damage checkpoint. For long the activity of this checkpoint was thought to be limited to the nucleus. In this and other emerging studies it has now been established that the DNA damage checkpoint can regulate cell cycle arrest, nuclear positioning and movement by controlling cytoplasmic factors and events. This study establishes a novel regulatory mechanism of the DNA damage checkpoint involving vesicular transport system and cytoplasmic, non-proteosomal protein degradation. The study also focuses on the connection between the spindle assembly checkpoint (SAC) and the DNA damage checkpoint. To study this we generate an acentric chromosome with a single DNA double strand break on it. We find that budding yeast cells that have one chromosome with conditional GAL1-Cen centromere turned off cannot activate the SAC and both the sister chromatids of this chromosome get preferentially segregated to the mother cell., Genetics (non-medical)<

ISBN: 383830277X

Nuclear and cytoplasmic control of the DNA damage checkpoint ab 67.99 € als Taschenbuch: A new way of looking at cell cycle control. Aus dem Bereich: Bücher, Wissenschaft, Biologie, Medie… More...

Nuclear and cytoplasmic control of the DNA damage checkpoint ab 67.99 € als Taschenbuch: A new way of looking at cell cycle control. Aus dem Bereich: Bücher, Wissenschaft, Biologie, Medien > Bücher, LAP LAMBERT Academic Publishing<

ISBN: 383830277X

Nuclear and cytoplasmic control of the DNA damage checkpoint ab 67.99 € als Taschenbuch: A new way of looking at cell cycle control. Aus dem Bereich: Bücher, Taschenbücher, Naturwissensch… More...

Nuclear and cytoplasmic control of the DNA damage checkpoint ab 67.99 € als Taschenbuch: A new way of looking at cell cycle control. Aus dem Bereich: Bücher, Taschenbücher, Naturwissenschaft, LAP LAMBERT Academic Publishing<

2009, ISBN: 383830277X

Kartoniert / Broschiert, mit Schutzumschlag 11, [PU:LAP LAMBERT Academic Publishing]