2012, ISBN: 9783659281662

[ED: Taschenbuch / Paperback], [PU: LAP Lambert Academic Publishing], An essential oil from a lemon grass variety of Cymbopogon flexuosus (CFO) and its major chemical constituent sesquite… More...

[ED: Taschenbuch / Paperback], [PU: LAP Lambert Academic Publishing], An essential oil from a lemon grass variety of Cymbopogon flexuosus (CFO) and its major chemical constituent sesquiterpene isointermedeol (ISO) were investigated for their ability to induce apoptosis in human leukaemia HL-60 cells because dysregulation of apoptosis is the hallmark of cancer cells. CFO and ISO inhibited cell proliferation with 48 h IC50 of 30 and 20 g/ml, respectively. Both induced concentration dependent strong and early apoptosis as measured by various end-points, e.g. annexinV binding, DNA laddering, apoptotic bodies formation and an increase in hypo diploid sub-G0 DNA content during the early 6 h period of study. This could be because of early surge in ROS formation with concurrent loss of mitochondrial membrane potential observed. Both CFO and ISO activated apical death receptors TNFR1, DR4 and caspase-8 activity. Simultaneously, both increased the expression of mitochondrial cytochrome c protein with its concomitant release to cytosol leading to caspase-9 activation, suggesting thereby the involvement of both the intrinsic and extrinsic pathways of apoptosis., DE, Neuware, gewerbliches Angebot, H: 220mm, B: 150mm, 272, Selbstabholung und Barzahlung, PayPal, Offene Rechnung, Banküberweisung, Internationaler Versand<

ISBN: 3659281662

[EAN: 9783659281662], Neubuch, Publisher/Verlag: LAP Lambert Academic Publishing | To Prevent Cancer Induce Apoptosis | An essential oil from a lemon grass variety of Cymbopogon flexuosus… More...

[EAN: 9783659281662], Neubuch, Publisher/Verlag: LAP Lambert Academic Publishing | To Prevent Cancer Induce Apoptosis | An essential oil from a lemon grass variety of Cymbopogon flexuosus (CFO) and its major chemical constituent sesquiterpene isointermedeol (ISO) were investigated for their ability to induce apoptosis in human leukaemia HL-60 cells because dysregulation of apoptosis is the hallmark of cancer cells. CFO and ISO inhibited cell proliferation with 48 h IC50 of 30 and 20 g/ml, respectively. Both induced concentration dependent strong and early apoptosis as measured by various end-points, e.g. annexinV binding, DNA laddering, apoptotic bodies formation and an increase in hypo diploid sub-G0 DNA content during the early 6 h period of study. This could be because of early surge in ROS formation with concurrent loss of mitochondrial membrane potential observed. Both CFO and ISO activated apical death receptors TNFR1, DR4 and caspase-8 activity. Simultaneously, both increased the expression of mitochondrial cytochrome c protein with its concomitant release to cytosol leading to caspase-9 activation, suggesting thereby the involvement of both the intrinsic and extrinsic pathways of apoptosis. | Format: Paperback | Language/Sprache: english | 272 pp<

ISBN: 9783659281662

Paperback, [PU: LAP Lambert Academic Publishing], An essential oil from a lemon grass variety of Cymbopogon flexuosus (CFO) and its major chemical constituent sesquiterpene isointermedeo… More...

Paperback, [PU: LAP Lambert Academic Publishing], An essential oil from a lemon grass variety of Cymbopogon flexuosus (CFO) and its major chemical constituent sesquiterpene isointermedeol (ISO) were investigated for their ability to induce apoptosis in human leukaemia HL-60 cells because dysregulation of apoptosis is the hallmark of cancer cells. CFO and ISO inhibited cell proliferation with 48 h IC50 of∼30 and 20 g/ml, respectively. Both induced concentration dependent strong and early apoptosis as measured by various end-points, e.g. annexinV binding, DNA laddering, apoptotic bodies formation and an increase in hypo diploid sub-G0 DNA content during the early 6 h period of study. This could be because of early surge in ROS formation with concurrent loss of mitochondrial membrane potential observed. Both CFO and ISO activated apical death receptors TNFR1, DR4 and caspase-8 activity. Simultaneously, both increased the expression of mitochondrial cytochrome c protein with its concomitant release to cytosol leading to caspase-9 activation, suggesting thereby the involvement of both the intrinsic and extrinsic pathways of apoptosis.<

ISBN: 9783659281662

In vitro Evaluation of Anti Cancer Activity of Cymbopogon flexuosus ab 79 EURO To Prevent Cancer Induce Apoptosis In vitro Evaluation of Anti Cancer Activity of Cymbopogon flexuosus ab 79… More...

In vitro Evaluation of Anti Cancer Activity of Cymbopogon flexuosus ab 79 EURO To Prevent Cancer Induce Apoptosis In vitro Evaluation of Anti Cancer Activity of Cymbopogon flexuosus ab 79 EURO To Prevent Cancer Induce Apoptosis Bücher > Wissenschaft > Medizin<

2012, ISBN: 3659281662

Kartoniert / Broschiert, mit Schutzumschlag neu, [PU:LAP Lambert Academic Publishing]