ISBN: 9783639091656

Non alcoholic fatty liver disease is the hepatic manifestation of metabolic syndrome that may progress from simple steatosis to nonalcoholic steatohepatitis, cirrhosis and hepatocellular … More...

Non alcoholic fatty liver disease is the hepatic manifestation of metabolic syndrome that may progress from simple steatosis to nonalcoholic steatohepatitis, cirrhosis and hepatocellular carcinoma. Expansion of omental adipose is accompanied by alteration in profiles of adipocytokines that contribute to NAFLD through enhanced steatogenesis in the liver and its inflammation. Gene transcription studies demonstrated a prominent adipose-specific deregulation of the inflammation and immune system related genes in NASH. Serum levels of soluble adipokines and cytokines can reliably predict NASH in the cohort of morbidly obese patients. Histologic fibrosis in patients with NASH could be predicted by TNF- level. There is also strong connection between the HCV genotype 3, steatosis and increases in IL-8 serum levels. HCV genotype specific differences in soluble cytokine concentrations may help to elucidate pathogenesis of HCV hepatitis and potential triggers for HCV-related steatosis. These results should be of interest to the researchers of the clinical and fundamental aspects of human metabolism, obesity, diabetes, and hepatitis C. Adipokines and Pathogenesis of Non Alcoholic Fatty Liver Disease Jarrar, Mohammed / Younossi, Zobair / Baranova, Ancha, VDM Verlag<

ISBN: 9783639091656

VDM Verlag Dr. Mueller e.K.. PAPERBACK. 3639091655 Special order direct from the distributor . New., VDM Verlag Dr. Mueller e.K.

ISBN: 9783639091656

VDM Verlag Dr. Mueller E.K.. Paperback. New. NEW BOOK, VDM Verlag Dr. Mueller E.K.