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The Role of Lipid Rafts in Canine Distemper Virus Infection - Heidi Imhoff
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The Role of Lipid Rafts in Canine Distemper Virus Infection - Paperback

ISBN: 3639046307

Taschenbuch, [EAN: 9783639046304], VDM Verlag, VDM Verlag, Book, [PU: VDM Verlag], VDM Verlag, 189312, Medizin, 296942, Chirurgie, 189376, Geschichte, 3820741, Intelligenz, 189421, Körper… More...

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The Role of Lipid Rafts in Canine Distemper Virus Infection - Heidi Imhoff
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Heidi Imhoff:

The Role of Lipid Rafts in Canine Distemper Virus Infection - Paperback

ISBN: 9783639046304

[ED: Taschenbuch], [PU: VDM Verlag], Neuware - Cholesterol is known to play an important role in stabilisingparticular cellular membrane structures, so-called lipid rafts. Forseveral viru… More...

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The Role of Lipid Rafts in Canine Distemper Virus Infection
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The Role of Lipid Rafts in Canine Distemper Virus Infection - new book

ISBN: 9783639046304

Cholesterol is known to play an important role in stabilisingparticular cellular membrane structures, so-called lipid rafts. Forseveral viruses a dependence on cholesterol for virus entry… More...

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The Role of Lipid Rafts in Canine Distemper Virus Infection - Imhoff, Heidi
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Imhoff, Heidi:
The Role of Lipid Rafts in Canine Distemper Virus Infection - Paperback

2008, ISBN: 9783639046304

Erscheinungsdatum: 08/2008, Medium: Taschenbuch, Einband: Kartoniert / Broschiert, Titel: The Role of Lipid Rafts in Canine Distemper Virus Infection, Autor: Imhoff, Heidi, Verlag: VDM Ve… More...

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The Role of Lipid Rafts in Canine Distemper Virus Infection
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The Role of Lipid Rafts in Canine Distemper Virus Infection - new book

ISBN: 3639046307

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The Role of Lipid Rafts in Canine Distemper Virus Infection

Cholesterol is known to play an important role in stabilising particular cellular membrane structures, so-called lipid rafts. For several viruses a dependence on cholesterol for virus entry and/or morphogenesis has been shown. Using flow cytometry and fluorescence microscopy we demonstrate that Canine distemper virus (CDV) infection of cells was not impaired after cellular cholesterol had been depleted by the drug methyl-beta-cyclodextrin (MbCD). This effect was independent of the multiplicity of infection (MOI) and the cellular receptor used for infection. However, cholesterol depletion of the viral envelope significantly reduced CDV infectivity. Replenishment by addition of exogenous cholesterol restored infectivity up to 80 percent. Thus, we conclude that CDV entry is dependent on cholesterol in the viral envelope. Furthermore, a reduced syncytium formation was observed when the cells were cholesterol depleted during the course of the infection. This may be related to the observation that the CDV envelope proteins H and F partitioned into cellular detergent resistant membranes (DRMs). Therefore, a role for lipid rafts during virus assembly and release as well is suggested.

Details of the book - The Role of Lipid Rafts in Canine Distemper Virus Infection


EAN (ISBN-13): 9783639046304
ISBN (ISBN-10): 3639046307
Paperback
Publishing year: 2008
Publisher: VDM Verlag
176 Pages
Weight: 0,278 kg
Language: eng/Englisch

Book in our database since 2008-01-17T09:57:09+00:00 (London)
Detail page last modified on 2020-02-17T14:10:01+00:00 (London)
ISBN/EAN: 3639046307

ISBN - alternate spelling:
3-639-04630-7, 978-3-639-04630-4
Alternate spelling and related search-keywords:
Book author: imhoff
Book title: virus, distemper, infectio, infection


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