Handbook of Neurochemistry and Molecular Neurobiology / Neuroimmunology / Armen Galoyan (u. a.) / Buch / HC runder Rücken kaschiert / XIII / Englisch / 2007 / Springer US / EAN 9780387303581 - hardcover

This volume contains data on multiple immunomodulators, many of which are also the products of hypothalamic brain cell neurosecretion. Interleukins (IL-1a, IL-1ß, IL-2, IL-4, IL-6, TNFa), immunophylin and ubiquitin as well as proline rich peptides, comprised of 10-15 amino acids are being produced in N. Supraopticus and N. Paraventricularis and then secreted into neurohypophysis. Along the neurosecretion of the mentioned cytokines, there are other immunomodulators, the primary structure of which had been completely deciphered such as: Immunophyllins, intracellular receptors of immunosuppressors FK506, cyclosporine A., rapamicin. They are peptidyl-prolyl-cis-trans-isomerases. There are novel immunological hypothalamic factors such as ubiquitin, macrophage migration inhibitory factor (MIF), as well as Thymosin ß 4(1-39). This data allowed us to propose the concept of neuroendocrine immune system of the brain. TOC:BRAIN CYTOKINES AS INTEGRATORS OF THE IMMUNE-NEUROENDOCRINE NETWORK - H. O. Besedovsky and A. del Rey.- NEUROPEPTIDES IN THE IMMUNE SYSTEM: MEDIATORS OF STRESS AND INFLAMMATION - D.S. Jessop.- EFFECTS OF THE IMMUNE SYSTEM ON BRAIN NEUROCHEMISTRY - A. J. Dunn.- AGE-RELATED ALTERATIONS IN AUTONOMIC NERVOUS SYSTEM INNERVATION OF LYMPHOID TISSUE - D. L. Bellinger, C. L. Lubahn, A. B. Millar, J. L. Carter, S. Vyas, S. D. Perez, and D. Lorton.- DRUGS THAT TARGET SYMPATHETIC-IMMUNE PATHWAYS FOR TREATMENT OF AUTOIMMUNE DISEASES - D. Lorton, C. Lubahn, and D. Bellinger.- NEURO-IMMUNE ASSOCIATIVE LEARNING - M.-B. Niemi, G. Pacheco-López, H. Engler, C. Riether, R. Doenlen, and M. Schedlowski.- THE BRAIN IMMUNE SYSTEM: CHEMISTRY AND BIOLOGY OF SIGNAL MOLECULES - A. Galoyan.- THE DIALECT OF IMMUNE SYSTEM IN THE CNS: THE NERVOUS TISSUE AS IMMUNE COMPARTMENT FOR T CELLS AND DENDRITIC CELLS - Z. Fabry, E. Reinke, A. Zozulya, M. Sandor, and I. Bechmann.- IMMUNOPROTEASOME ACTIVITY IN THE NERVOUS SYSTEM - M. T. Rinaudo and M. Piccinini.- REGULATION OF THE INFLAMMATORY RESPONSE IN BRAIN - W. Stenzel and G. Alber.- EVOLUTIONARY ORIGINS OF THE BRAIN'S IMMUNE PRIVILEGE. IMPLICATIONS FOR NOVEL THERAPEUTIC APPROACHES: GENE THERAPY - P. R. Lowenstein, K. Kroeger, C. Barcia, J. Zirger, D. Larocque, and M. G. Castro.- ADENOSINE: AN ENDOGENOUS REGULATOR OF THE BRAIN IMMUNE SYSTEM - G. Haskó and E. S. Vizi.- NEUROIMMUNE CROSS TALK - G. Juhász.- ROLE OF GLIA IN CNS INFLAMMATION - S. Pawate and N. R. Bhat.- AUTOIMMUNE PROCESSES IN THE CENTRAL NERVOUS SYSTEM - C. J. Welsh and C. R. Young.- EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS - B. Gran, K. O'Brian, D. Fitzgerald, and A. Rostami.- IMMUNOLOGICAL ASPECTS OF CENTRAL NERVOUS SYSTEM DEMYELINATION - S. Pawate and S. Sriram.- THE INFLAMMATORY COMPONENT OF NEURODEGENERATIVE DISEASES - C. C. Ferrari and F. J. Pitossi.- MECHANISMS OF INFLAMMATION IN HIV-ASSOCIATED DEMENTIA - B. Giunta, F. Fernandez, and J. Tan.- ROLE OF POLY(ADP-RIBOSE) POLYMERASE IN BRAIN INFLAMMATION AND NEUROINJURY - G. S. Scott, K. Komjáti, V. C. Besson, and C. Szabó.- SCHIZOPHRENIA AND IMMUNE RESPONSES - F. Gaughran, J. Welch