2012, ISBN: 9783527330294

[ED: Buch, gebundene Ausgabe], [PU: Wiley-VCH], AUSFÜHRLICHERE BESCHREIBUNG: Cost-effective manufacturing of biopharmaceutical products is rapidly gaining in importance, while healthcare … More...

[ED: Buch, gebundene Ausgabe], [PU: Wiley-VCH], AUSFÜHRLICHERE BESCHREIBUNG: Cost-effective manufacturing of biopharmaceutical products is rapidly gaining in importance, while healthcare systems across the globe are looking to contain costs and improve efficiency. To adapt to these changes, industries need to review and streamline their manufacturing processes. This two volume handbook systematically addresses the key steps and challenges in the production process and provides valuable information for medium to large scale producers of biopharmaceuticals. It is divided into seven major parts: - Upstream Technologies - Protein Recovery - Advances in Process Development - Analytical Technologies - Quality Control - Process Design and Management - Changing Face of Processing With contributions by around 40 experts from academia as well as small and large biopharmaceutical companies, this unique handbook is full of first-hand knowledge on how to produce biopharmaceuticals in a cost-effective and quality-controlled manner. INHALT: PREFACE Volume 1 PART ONE: Upstream Technologies STRATEGIES FOR PLASMID DNA PRODUCTION IN ESCHERICHIA COLI Introduction Requirements for a Plasmid DNA Production Process Structure of a DNA Vaccine Production Process Choice of Antigen Vector DNA Construct Host Strains Cultivation Medium and Process Conditions Lysis/Extraction of Plasmid DNA Purification Formulation Conclusions ADVANCES IN PROTEIN PRODUCTION TECHNOLOGIES Introduction Glycoengineering for Homogenous Human-Like Glycoproteins Bacteria as Protein Factories Mammalian Cell Technology Yeast Protein Production Baculovirus - Insect Cell Technology Transgenic Animal Protein Production Plant Molecular Farming Cell-Free Protein Production Future Prospects PART TWO: Protein Recovery RELEASING BIOPHARMACEUTICAL PRODUCTS FROM CELLS Introduction Cell Structure and Strategies for Disruption Cell Mechanical Strength Homogenization Bead Milling Chemical Treatment Cellular Debris Conclusions CONTINUOUS CHROMATOGRAPHY (MULTICOLUMN COUNTERCURRENT SOLVENT GRADIENT PURIFI CATION) FOR PROTEIN PURIFI CATION Introduction Overview of Continuous Chromatographic Processes Principles of MCSGP Application Examples of MCSGP Enabling Features and Economic Impact of MCSGP Annex 1: Chromatographic Process Decision Tree VIRUS-LIKE PARTICLE BIOPROCESSING Introduction Upstream Processing Downstream Processing Analysis Conclusions Nomenclature THERAPEUTIC PROTEIN STABILITY AND FORMULATION Introduction Protein Stability Formulation and Materials Screening Methods Accelerated and Long-Term Stability Testing Analytical Techniques for Stability Testing Conclusions PRODUCTION OF PEGYLATED PROTEINS Introduction General Considerations PEGylation Chemistry PEGylated Protein Purification Conclusions PART THREE: Advances in Process Development AFFINITY CHROMATOGRAPHY: HISTORICAL AND PROSPECTIVE OVERVIEW History and Role of Affinity Chromatography in the Separation Sciences Overview of Affinity Chromatography: Theory and Methods Affinity Ligands Affinity Ligands in Practice: Biopharmaceutical Production Conclusions and Future Perspectives HYDROXYAPATITE IN BIOPROCESSING Introduction Materials and Interaction Mechanisms Setting up a Separation Separation Examples Conclusions MONOLITHS IN BIOPROCESSING Introduction Properties of Chromatographic Monoliths Monolithic Analytical Columns for Process Analytical Technology Applications Monoliths for Preparative Chromatography Enzyme Reactors Conclusions MEMBRANE CHROMATOGRAPHY FOR BIOPHARMACEUTICAL MANUFACTURING Membrane Adsorbers - Introduction and Technical Specifications Comparing Resins and Membrane Adsorbers Membrane Chromatography Applications and Case Studies Conclusions MODELING AND EXPERIMENTAL MODEL PARAMETER DETERMINATION WITH QUALITY BY DESIGN FOR BIOPROCESSES Introduction QbD Fundamentals Process Modeling and Experimental Model Parameter Determination Process Robustness Study Conclusions Nomenclature Volume 2 PART FOUR: Analytical Technologies BIOSENSORS IN THE PROCESSING AND ANALYSIS OF BIOPHARMACEUTICALS Introduction Principles and Commercial Applications of Biosensors Use of Biosensors in Biopharmaceutical Production and Processing Conclusions PROTEOMICS TOOLKIT: APPLICATIONS IN PROTEIN BIOLOGICAL PRODUCTION AND METHOD DEVELOPMENT Introduction Applications of Proteomics Myths and Misconceptions - Perceived Drawbacks of Proteomics Critical Factors for Industrialization of Proteomics Case Studies Conclusions SCIENCE OF PROTEOMICS: HISTORICAL PERSPECTIVES AND POSSIBLE ROLE IN HUMAN HEALTHCARE Science of 'Omics' Major Advances in Biology That Led to the Sciences of 'Omics' Mendel's Principles of Inheritance One Gene/One Enzyme Concept of Beadle and Tatum Watson - Crick Structure of DNA Development of Different Technologies Responsible for the Emergence of Genomics and Proteomics Genomics Proteomics Interactomics: Complexity of an Organism B, DE, [SC: 0.00], Neuware, gewerbliches Angebot, H: 244mm, B: 177mm, T: 51mm, 884, [GW: 2060g], Selbstabholung und Barzahlung, PayPal, Offene Rechnung, Banküberweisung, Internationaler Versand<

2012, ISBN: 9783527330294

Cost-effective manufacturing of biopharmaceutical products is rapidly gaining in importance, while healthcare systems across the globe are looking to contain costs and improve efficiency.… More...

Cost-effective manufacturing of biopharmaceutical products is rapidly gaining in importance, while healthcare systems across the globe are looking to contain costs and improve efficiency. To adapt to these changes, industries need to review and streamline their manufacturing processes. This two volume handbook systematically addresses the key steps and challenges in the production process and provides valuable information for medium to large scale producers of biopharmaceuticals. It is divided into seven major parts: - Upstream Technologies - Protein Recovery - Advances in Process Development - Analytical Technologies - Quality Control - Process Design and Management - Changing Face of Processing With contributions by around 40 experts from academia as well as small and large biopharmaceutical companies, this unique handbook is full of first-hand knowledge on how to produce biopharmaceuticals in a cost-effective and quality-controlled manner. Buch (fremdspr.) Ganapathy Subramanian gebundene Ausgabe, Wiley-VCH, 18.07.2012, Wiley-VCH, 2012<

ISBN: 9783527330294

Biopharmaceutical Production Technology, 2 Volume Set Hardcover New Books, Wiley-VCH

2012, ISBN: 9783527330294

Hardcover

Buch, Hardcover, 1. Auflage, [PU: Wiley-VCH], Wiley-VCH, 2012

2012, ISBN: 9783527330294

Hardcover

[ED: 1], 1. Auflage, Hardcover, Buch, [PU: Wiley-VCH]