Prodrugs and Targeted Delivery - hardcover

EAN (ISBN-13): 9783527326037
ISBN (ISBN-10): 3527326030
Hardcover
Publishing year: 2010
Publisher: Rautio, Jarkko, Wiley-VCH
496 Pages
Weight: 1,104 kg
Language: eng/Englisch

Book in our database since 2007-01-16T11:28:29+00:00 (London)
Detail page last modified on 2023-09-23T09:37:34+01:00 (London)
ISBN/EAN: 9783527326037

ISBN - alternate spelling:
3-527-32603-0, 978-3-527-32603-7
Alternate spelling and related search-keywords:
Book author: kubinyi, rauti, raimund, hugo, wiley vch, gerd folkers
Book title: delivery beyond, principles chemistry

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Information from Publisher

Author: Jarkko Rautio
Title: Methods and Principles in Medicinal Chemistry; Prodrugs and Targeted Delivery - Towards Better ADME Properties
Publisher: Wiley-VCH; Wiley-VCH
496 Pages
Publishing year: 2010-12-15
Printed / Made in
Weight: 1,432 kg
Language: English
185,00 € (DE)
190,20 € (AT)
Available
170mm x 240mm x 39mm

BB; Hardcover, Softcover / Chemie; Medizinische Chemie, Pharmazeutische Chemie; Verstehen; Medizin, Gesundheit; Arzneimittelentwicklung; Arzneimittelforschung; Chemie; Chemistry; Drug Discovery & Development; Drug Formulation & Delivery; Toxicology; Toxikologie; Wirkstoff; Wirkstoffformulierung, Wirkstofftransport; Wirkstoffforschung u. -entwicklung; Wirkstoffforschung u. -entwicklung; Wirkstoffformulierung, Wirkstofftransport; Toxikologie

By definition, drugs are highly active substances that are beneficial if they act at the right time and in the right place, but can cause harm otherwise. A clever strategy to ensure that a drug only becomes active when needed is to "camouflage" it. Such camouflaged, i.e. deactivated, drugs that become chemically or biochemically activated once they reach their site of action are called prodrugs. This topical reference and handbook addresses the chemistry, pharmacology, toxicology and the patentability of prodrugs, perfectly mirroring the integrated approach prevalent in today's drug design. It summarizes current experiences and strategies, beginning at the early stages of the development process, while also discussing organ- and site-selective prodrugs. From the contents: * Prodrug design and intellectual property * Prodrugs addressing ADMET issues * Codrugs and soft drugs * Preclinical and clinical consideration for prodrugs This book is a valuable reference for all companies employing medicinal chemists by giving a practice-oriented overview of a key strategy in modern drug discovery and development.