2012, ISBN: 9781461433453

eBooks, eBook Download (PDF), 2012, In multicellular organisms the establishment, maintenance, and programmed alterations of cell-type specific gene expression patterns are regulated by e… More...

eBooks, eBook Download (PDF), 2012, In multicellular organisms the establishment, maintenance, and programmed alterations of cell-type specific gene expression patterns are regulated by epigenetic mechanisms. Thus, epigenetic alterations (DNA methylation, DNA associated Polycomb-Trithorax protein complexes, histone modifications) ensure the unique transcriptional activity and phenotypic diversity of diploid cells that carry identical or nearly identical DNA sequences.Because DNA methyltransferase I (DNMT1) associates with replication foci during S phase and prefers hemimethylated DNA as a substrate, DNMT1 ensures the clonal propagation of cytosine methylation patterns (maintenance methylation). Thus, DNA methylation may provide a memory function by helping progeny cells to &quote;remember&quote; their proper cellular identity. An alternative system of epigenetic memory, the Polycomb and Trithorax groups of protein complexes, that may operate both independently from and in concert with DNA methylation, ensures the heritable regulation of gene expression via modification of histone tails. The complex interplay of epigenetic regulatory mechanisms permits both the dynamic modulation of gene expression and the faithful transmission of gene expression patterns to each progeny cell upon division. These carefully orchestrated processes can go wrong, however, resulting in epigenetic reprogramming of the cells that may manifest in pathological changes, as it was first realized during the studies of epigenetic alterations in malignant tumors. By now it became a well established fact that not only genetic changes, but also the disruption of epigenetic regulation can result in carcinogenesis and tumor progression. Scientists working in other fields soon followed the pioneering work of cancer researchers, and revealed that epigenetic dysregulation forms the basis of a wide spectrum of human diseases. [PU: Springer New York], Seiten: 466, Springer New York, 2012<

ISBN: 9781461433453

In multicellular organisms the establishment, maintenance, and programmed alterations of cell-type specific gene expression patterns are regulated by epigenetic mechanisms. Thus, epigenet… More...

In multicellular organisms the establishment, maintenance, and programmed alterations of cell-type specific gene expression patterns are regulated by epigenetic mechanisms. Thus, epigenetic alterations (DNA methylation, DNA associated Polycomb-Trithorax protein complexes, histone modifications) ensure the unique transcriptional activity and phenotypic diversity of diploid cells that carry identical or nearly identical DNA sequences.Because DNA methyltransferase I (DNMT1) associates with replication foci during S phase and prefers hemimethylated DNA as a substrate, DNMT1 ensures the clonal propagation of cytosine methylation patterns (maintenance methylation). Thus, DNA methylation may provide a memory function by helping progeny cells to "remember" their proper cellular identity. An alternative system of epigenetic memory, the Polycomb and Trithorax groups of protein complexes, that may operate both independently from and in concert with DNA methylation, ensures the heritable regulation of gene expression via modification of histone tails. The complex interplay of epigenetic regulatory mechanisms permits both the dynamic modulation of gene expression and the faithful transmission of gene expression patterns to each progeny cell upon division. These carefully orchestrated processes can go wrong, however, resulting in epigenetic reprogramming of the cells that may manifest in pathological changes, as it was first realized during the studies of epigenetic alterations in malignant tumors. By now it became a well established fact that not only genetic changes, but also the disruption of epigenetic regulation can result in carcinogenesis and tumor progression. Scientists working in other fields soon followed the pioneering work of cancer researchers, and revealed that epigenetic dysregulation forms the basis of a wide spectrum of human diseases.; PDF; Scientific, Technical and Medical > Clinical & internal medicine > Diseases & disorders > Infectious, Springer US<

ISBN: 9781461433453

This book describes the complex interplay of epigenetic regulatory mechanisms, and shows how these carefully orchestrated processes can go wrong, resulting in epigenetic reprogramming of … More...

This book describes the complex interplay of epigenetic regulatory mechanisms, and shows how these carefully orchestrated processes can go wrong, resulting in epigenetic reprogramming of the cells that may manifest in pathological changes.; EPUB; Scientific, Technical and Medical > Clinical & internal medicine > Diseases & disorders > Infectious, AltaMira Press<

ISBN: 9781461433453

*Patho-Epigenetics of Disease* / pdf eBook für 149.99 € / Aus dem Bereich: eBooks, Fachthemen & Wissenschaft, Medizin Medien > Bücher nein eBook als pdf eBooks > Fachthemen & Wissenschaft… More...

*Patho-Epigenetics of Disease* / pdf eBook für 149.99 € / Aus dem Bereich: eBooks, Fachthemen & Wissenschaft, Medizin Medien > Bücher nein eBook als pdf eBooks > Fachthemen & Wissenschaft > Medizin, Springer-Verlag GmbH<

ISBN: 9781461433453

Patho-Epigenetics of Disease: ab 149.99 € eBooks > Fachthemen & Wissenschaft > Medizin Springer-Verlag GmbH eBook als pdf, Springer-Verlag GmbH