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Ryanodine Receptors: Structure, function and dysfunction in clinical disease (Developments in Cardiovascular Medicine, 254, Band 254)
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Ryanodine Receptors: Structure, function and dysfunction in clinical disease (Developments in Cardiovascular Medicine, 254, Band 254) - hardcover

2004, ISBN: 9780387231877

Springer, Gebundene Ausgabe, Auflage: 2005, 351 Seiten, Publiziert: 2004-11-09T00:00:01Z, Produktgruppe: Buch, Hersteller-Nr.: 13285455, 1.49 kg, Thorax & Gefäßchirurgie, Chirurgie, Mediz… More...

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Ryanodine Receptors: Structure, function and dysfunction in clinical disease (Developments in Cardiovascular Medicine, 254, Band 254)
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Ryanodine Receptors: Structure, function and dysfunction in clinical disease (Developments in Cardiovascular Medicine, 254, Band 254) - hardcover

2004, ISBN: 9780387231877

Springer, Gebundene Ausgabe, Auflage: 2005, 351 Seiten, Publiziert: 2004-11-09T00:00:01Z, Produktgruppe: Buch, Hersteller-Nr.: 13285455, 3.28 kg, Thorax & Gefäßchirurgie, Chirurgie, Mediz… More...

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Ryanodine Receptors: Structure, function and dysfunction in clinical disease (Developments in Cardiovascular Medicine, 254, Band 254)
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Ryanodine Receptors: Structure, function and dysfunction in clinical disease (Developments in Cardiovascular Medicine, 254, Band 254) - hardcover

2004

ISBN: 9780387231877

Springer, Gebundene Ausgabe, Auflage: 2005, 351 Seiten, Publiziert: 2004-11-09T00:00:01Z, Produktgruppe: Buch, Hersteller-Nr.: 13285455, 3.28 kg, Thorax & Gefäßchirurgie, Chirurgie, Mediz… More...

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Ryanodine Receptors: Structure, function and dysfunction in clinical disease (Developments in Cardiovascular Medicine) - hardcover

2004, ISBN: 9780387231877

Springer, 2004-11-09. Hardcover. Good. 0.9000 9.4000 6.2000. Book has moderate wear., Springer, 2004-11-09, 2.5

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Ryanodine Receptors - First edition

ISBN: 9780387231877

Hardcover

Springer , pp. xxi + 330 1st Edition . Hardback. New., Springer, 6

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Ryanodine Receptors: Structure, function and dysfunction in clinical disease (Developments in Cardiovascular Medicine, 254, Band 254)

In recent years, the ryanodine receptor has emerged as a new and very promising target for the treatment of several cardiovascular disorders, including cardiac arrhythmias and heart failure. This volume is the most current publication devoted to the major intracellular calcium-release channel, the ryanodine receptor."In this series of brief but informative chapters, the contributions progress from the basic gene family and primary structure, through its 3D structure so far, to its regulation and physiology." David E. Clapham, MD, PhDProfessor of Neurobiology and PediatricsHarvard Medical SchoolDr. Xander H.T. Wehrens received his M.D. and Ph.D. degrees from Maastricht University in the Netherlands. His research has mainly concentrated on molecular mechanisms of cardiac arrhythmias, in particular in the setting of inherited arrhythmogenic syndromes and congestive heart failure. This work has led to the development of novel anti-arrhythmic therapies. He is currently a research scientist in the Department of Physiology and Cellular Biophysics at the College of Physicians and Surgeons of Columbia University.Dr. Andrew R. Marks is the Chair and Professor of the Department of Physiology and Cellular Biophysics at Columbia University College of Physicians and Surgeons. Dr. Marks' research has focused on understanding how macromolecular signaling complexes regulate ion channel function in muscle and non-muscle systems, and on the regulation of vascular smooth muscle proliferation and migration. His work has contributed new understandings of fundamental mechanisms that regulate muscle contraction that have lead to the discovery of molecular defects that contribute to heart failure and fatal cardiac arrhythmias.

Details of the book - Ryanodine Receptors: Structure, function and dysfunction in clinical disease (Developments in Cardiovascular Medicine, 254, Band 254)


EAN (ISBN-13): 9780387231877
ISBN (ISBN-10): 0387231870
Hardcover
Paperback
Publishing year: 2010
Publisher: Wehrens, Xander H. T. Marks, Andrew R. Springer
330 Pages
Weight: 0,760 kg
Language: eng/Englisch

Book in our database since 2007-05-30T16:52:46+01:00 (London)
Detail page last modified on 2024-03-06T21:29:18+00:00 (London)
ISBN/EAN: 9780387231877

ISBN - alternate spelling:
0-387-23187-0, 978-0-387-23187-7
Alternate spelling and related search-keywords:
Book author: wehrens, wehr, huhn, hühn susanne, wehren, xander, andre marks, andré marks
Book title: development disease, dysfunction, receptors structure function, ryanodine receptors, structure and function, rya


Information from Publisher

Author: Xander H. T. Wehrens
Title: Developments in Cardiovascular Medicine; Ryanodine Receptors - Structure, function and dysfunction in clinical disease
Publisher: Springer; Springer US
330 Pages
Publishing year: 2004-11-09
New York; NY; US
Printed / Made in
Weight: 1,490 kg
Language: English
164,99 € (DE)

BB; Cardiology; Hardcover, Softcover / Medizin/Klinische Fächer; Kardiologie, Angiologie; Verstehen; cardiovascular; pathophysiology; physiology; skeletal muscle; smooth muscle; Cardiology; BC; EA

Evolution of the ryanodine receptor gene family.- Topology and transmembrane organization of ryanodine receptors.- Three-dimensional reconstruction of ryanodine receptors.- RyR-DHPR relationships in skeletal and cardiac muscles.- The pore of the ryanodine receptor channel.- Inter-molecular domain-domain interaction: A key mechanism for calcium channel regulation of ryanodine receptors.- Regulation of sarcoplasmic reticulum calcium release by luminal calcium.- Cytosolic calcium regulation of single ryanodine receptor channels.- Elementary calcium release events: ryanodine receptor Ca2+ sparks.- Ca2+ release from the sarcoplasmic reticulum in intact cardiomyocytes.- Stability and instability of Ca2+ release from the SR.- Ryanodine receptors in smooth muscle.- Functions of RyR3 homologues.- Knockout mice lacking RyR and junctophilin subtypes.- Regulation of ryanodine receptor Ca22+ release by macromolecular complexes.- RyR1 modulation by calmodulin.- Ryanodine receptor function in inflammation.- Ryanoids, receptor affinity and RyR channel subconductance: Why the discordance?- Scorpion peptides as high-affinity probes of ryanodine receptor function.- Redox sensing by the ryanodine receptors.- Ryanodine receptor dysfunctin in the diabetic heart.- Molecular and clinical genetics of RyR1 disorders.- Pathophysiology of muscle disorders linked to mutations in the skeletal muscle ryanodine receptor.- The dantrolene binding site on RyR1: Implications for clinical therapy.- Ryanodine receptor dysfunction in heart failure and arrhythmias.- Stabilization of ryanodine receptor as a novel therapeutic strategy against heart failure.- Ryanodine receptor antibodies and myasthenia gravis.

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